St. John's is the capital and largest city of Antigua and Barbuda, a country located in the West Indies in the Caribbean Sea. St. John's is located at 17°7′N 61°51′WCoordinates: 17°7′N 61°51′W. With a population of 24,226 (2000), St. John's is the commercial centre of the nation and the chief port of the island of Antigua.